The Best Road Trip Routes in the U.S. for 2025

Few adventures capture the spirit of freedom quite like a road trip. The open road, diverse landscapes, and quirky roadside attractions make it an unforgettable way to see the country. In 2025, these routes stand out for their beauty, culture, and unique stops along the way.

Route 66: The Classic American Road Trip

No list is complete without the legendary Route 66. Stretching from Chicago to Santa Monica, this route offers a nostalgic journey through small towns, neon diners, and roadside Americana. Highlights include Cadillac Ranch in Texas, Petrified Forest National Park in Arizona, and the Santa Monica Pier in California. Route 66 combines history with an unbeatable sense of adventure.

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Pacific Coast Highway: California’s Scenic Gem

The Pacific Coast Highway delivers jaw-dropping ocean views from San Francisco to Los Angeles. Drivers can stop at Big Sur’s dramatic cliffs, explore Monterey’s historic Cannery Row, and stroll Santa Barbara’s beaches. The combination of coastal beauty and cultural attractions makes this route a bucket-list favorite.

Big Sur’s coastline is among the most scenic protected stretches in the U.S., making this road trip a must for nature lovers.

Blue Ridge Parkway: Nature at Its Best

Known as “America’s Favorite Drive,” the Blue Ridge Parkway winds through Virginia and North Carolina with sweeping mountain views. Along the way, travelers can hike to waterfalls, explore charming Appalachian towns, and catch vibrant fall foliage. Its slower pace is perfect for those who want to relax and enjoy nature.

Great River Road: Following the Mighty Mississippi

Tracing the Mississippi River from Minnesota to Louisiana, the Great River Road showcases America’s heartland. Stops include Mark Twain’s hometown in Missouri, Memphis for live blues music, and New Orleans for its iconic cuisine and culture. This journey blends history, music, and culinary delights into one unforgettable experience.

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Underrated Route: Oregon’s Scenic Byways

For travelers seeking a less crowded experience, Oregon’s scenic byways offer volcanic landscapes, lush forests, and dramatic coastlines. Routes such as the Cascade Lakes Scenic Byway and the Historic Columbia River Highway provide access to waterfalls, hiking trails, and charming small towns. These drives highlight the state’s natural beauty while staying off the beaten path.

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Southwest National Parks Loop

For those who love desert landscapes, the Southwest offers one of the most striking road trip circuits. Starting in Las Vegas, you can loop through Zion, Bryce Canyon, Arches, and the Grand Canyon. Each park offers unique geological wonders, ranging from towering red rock formations to deep canyons carved over millions of years. This route is perfect for adventurers seeking natural beauty and outdoor activities.

Alaska’s Seward Highway

Few drives rival the raw beauty of Alaska’s Seward Highway, running from Anchorage to Seward. Travelers are treated to breathtaking views of glaciers, fjords, and wildlife, including moose and bald eagles. Stop at Turnagain Arm for tidal bore watching or explore Kenai Fjords National Park at the journey’s end. Remote yet accessible, this route showcases America’s last frontier spectacularly.

Key Takeaways

From iconic highways to hidden gems, America’s road trips in 2025 promise adventure for every type of traveler. Whether you crave history, coastal views, mountain landscapes, or cultural immersion, the route you choose can transform a simple drive into a once-in-a-lifetime journey.

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